Last data update: May 06, 2024. (Total: 46732 publications since 2009)
Records 1-4 (of 4 Records) |
Query Trace: de Mora D[original query] |
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Incidence and seasonality of respiratory viruses among medically attended children with acute respiratory infections in an Ecuador birth cohort, 2011-2014
Azziz-Baumgartner E , Bruno A , Daugherty M , Chico ME , Lopez A , Arriola CS , de Mora D , Ropero AM , Davis WW , McMorrow M , Cooper PJ . Influenza Other Respir Viruses 2021 16 (1) 24-33 BACKGROUND: Ecuador annually has handwashing and respiratory hygiene campaigns and seasonal influenza vaccination to prevent respiratory virus illnesses but has yet to quantify disease burden and determine epidemic timing. METHODS: To identify respiratory virus burden and assess months with epidemic activity, we followed a birth cohort in northwest Ecuador during 2011-2014. Mothers brought children to the study clinic for routine checkups at ages 1, 2, 3, 5, and 8 years or if children experienced any acute respiratory illness symptoms (e.g., cough, fever, or difficulty breathing); clinical care was provided free of charge. Those with medically attended acute respiratory infections (MAARIs) were tested for common respiratory viruses via real-time reverse-transcription polymerase chain reaction (rRT-PCR). RESULTS: In 2011, 2376 children aged 1-4 years (median 35 months) were enrolled in the respiratory cohort and monitored for 7017.5 child-years (cy). The incidence of respiratory syncytial virus (RSV) was 23.9 (95% CI 17.3-30.5), influenza 10.6 (2.4-18.8), adenoviruses 6.7 (4.6-28.0), parainfluenzas 5.0 (2.3-10.5), and rhinoviruses, bocaviruses, human metapneumoviruses, seasonal coronaviruses, and enteroviruses <3/100 cy among children aged 12-23 months and declined with age. Most (75%) influenza detections occurred April-September. CONCLUSION: Cohort children frequently had MAARIs, and while the incidence decreased rapidly among older children, more than one in five children aged 12-23 months tested positive for RSV, and one in 10 tested positive for influenza. Our findings suggest this substantial burden of influenza occurred more commonly during the winter Southern Hemisphere influenza season. |
The epidemiological signature of influenza B virus and its B/Victoria and B/Yamagata lineages in the 21st century
Caini S , Kusznierz G , Garate VV , Wangchuk S , Thapa B , de Paula Junior FJ , Ferreira de Almeida WA , Njouom R , Fasce RA , Bustos P , Feng L , Peng Z , Araya JL , Bruno A , de Mora D , Barahona de Gamez MJ , Pebody R , Zambon M , Higueros R , Rivera R , Kosasih H , Castrucci MR , Bella A , Kadjo HA , Daouda C , Makusheva A , Bessonova O , Chaves SS , Emukule GO , Heraud JM , Razanajatovo NH , Barakat A , El Falaki F , Meijer A , Donker GA , Huang QS , Wood T , Balmaseda A , Palekar R , Arevalo BM , Rodrigues AP , Guiomar R , Lee VJM , Ang LW , Cohen C , Treurnicht F , Mironenko A , Holubka O , Bresee J , Brammer L , Le MTQ , Hoang PVM , El Guerche-Seblain C , Paget J . PLoS One 2019 14 (9) e0222381 We describe the epidemiological characteristics, pattern of circulation, and geographical distribution of influenza B viruses and its lineages using data from the Global Influenza B Study. We included over 1.8 million influenza cases occurred in thirty-one countries during 2000-2018. We calculated the proportion of cases caused by influenza B and its lineages; determined the timing of influenza A and B epidemics; compared the age distribution of B/Victoria and B/Yamagata cases; and evaluated the frequency of lineage-level mismatch for the trivalent vaccine. The median proportion of influenza cases caused by influenza B virus was 23.4%, with a tendency (borderline statistical significance, p = 0.060) to be higher in tropical vs. temperate countries. Influenza B was the dominant virus type in about one every seven seasons. In temperate countries, influenza B epidemics occurred on average three weeks later than influenza A epidemics; no consistent pattern emerged in the tropics. The two B lineages caused a comparable proportion of influenza B cases globally, however the B/Yamagata was more frequent in temperate countries, and the B/Victoria in the tropics (p = 0.048). B/Yamagata patients were significantly older than B/Victoria patients in almost all countries. A lineage-level vaccine mismatch was observed in over 40% of seasons in temperate countries and in 30% of seasons in the tropics. The type B virus caused a substantial proportion of influenza infections globally in the 21st century, and its two virus lineages differed in terms of age and geographical distribution of patients. These findings will help inform health policy decisions aiming to reduce disease burden associated with seasonal influenza. |
Distribution of influenza virus types by age using case-based global surveillance data from twenty-nine countries, 1999-2014
Caini S , Spreeuwenberg P , Kusznierz GF , Rudi JM , Owen R , Pennington K , Wangchuk S , Gyeltshen S , Ferreira de Almeida WA , Pessanha Henriques CM , Njouom R , Vernet MA , Fasce RA , Andrade W , Yu H , Feng L , Yang J , Peng Z , Lara J , Bruno A , de Mora D , de Lozano C , Zambon M , Pebody R , Castillo L , Clara AW , Matute ML , Kosasih H , Nurhayati , Puzelli S , Rizzo C , Kadjo HA , Daouda C , Kiyanbekova L , Ospanova A , Mott JA , Emukule GO , Heraud JM , Razanajatovo NH , Barakat A , El Falaki F , Huang SQ , Lopez L , Balmaseda A , Moreno B , Rodrigues AP , Guiomar R , Ang LW , Lee VJM , Venter M , Cohen C , Badur S , Ciblak MA , Mironenko A , Holubka O , Bresee J , Brammer L , Hoang PVM , Le MTQ , Fleming D , Seblain CE , Schellevis F , Paget J . BMC Infect Dis 2018 18 (1) 269 BACKGROUND: Influenza disease burden varies by age and this has important public health implications. We compared the proportional distribution of different influenza virus types within age strata using surveillance data from twenty-nine countries during 1999-2014 (N=358,796 influenza cases). METHODS: For each virus, we calculated a Relative Illness Ratio (defined as the ratio of the percentage of cases in an age group to the percentage of the country population in the same age group) for young children (0-4 years), older children (5-17 years), young adults (18-39 years), older adults (40-64 years), and the elderly (65+ years). We used random-effects meta-analysis models to obtain summary relative illness ratios (sRIRs), and conducted meta-regression and sub-group analyses to explore causes of between-estimates heterogeneity. RESULTS: The influenza virus with highest sRIR was A(H1N1) for young children, B for older children, A(H1N1)pdm2009 for adults, and (A(H3N2) for the elderly. As expected, considering the diverse nature of the national surveillance datasets included in our analysis, between-estimates heterogeneity was high (I(2)>90%) for most sRIRs. The variations of countries' geographic, demographic and economic characteristics and the proportion of outpatients among reported influenza cases explained only part of the heterogeneity, suggesting that multiple factors were at play. CONCLUSIONS: These results highlight the importance of presenting burden of disease estimates by age group and virus (sub)type. |
Temporal patterns of influenza A and B in tropical and temperate countries: What are the lessons for influenza vaccination?
Caini S , Andrade W , Badur S , Balmaseda A , Barakat A , Bella A , Bimohuen A , Brammer L , Bresee J , Bruno A , Castillo L , Ciblak MA , Clara AW , Cohen C , Cutter J , Daouda C , de Lozano C , De Mora D , Dorji K , Emukule GO , Fasce RA , Feng L , Ferreira de Almeida WA , Guiomar R , Heraud JM , Holubka O , Huang QS , Kadjo HA , Kiyanbekova L , Kosasih H , Kusznierz G , Lara J , Li M , Lopez L , Mai Hoang PV , Pessanha Henriques CM , Matute ML , Mironenko A , Moreno B , Mott JA , Njouom R , Nurhayati , Ospanova A , Owen R , Pebody R , Pennington K , Puzelli S , Quynh Le MT , Razanajatovo NH , Rodrigues A , Rudi JM , Tzer Pin Lin R , Venter M , Vernet MA , Wangchuk S , Yang J , Yu H , Zambon M , Schellevis F , Paget J . PLoS One 2016 11 (3) e0152310 INTRODUCTION: Determining the optimal time to vaccinate is important for influenza vaccination programmes. Here, we assessed the temporal characteristics of influenza epidemics in the Northern and Southern hemispheres and in the tropics, and discuss their implications for vaccination programmes. METHODS: This was a retrospective analysis of surveillance data between 2000 and 2014 from the Global Influenza B Study database. The seasonal peak of influenza was defined as the week with the most reported cases (overall, A, and B) in the season. The duration of seasonal activity was assessed using the maximum proportion of influenza cases during three consecutive months and the minimum number of months with ≥80% of cases in the season. We also assessed whether co-circulation of A and B virus types affected the duration of influenza epidemics. RESULTS: 212 influenza seasons and 571,907 cases were included from 30 countries. In tropical countries, the seasonal influenza activity lasted longer and the peaks of influenza A and B coincided less frequently than in temperate countries. Temporal characteristics of influenza epidemics were heterogeneous in the tropics, with distinct seasonal epidemics observed only in some countries. Seasons with co-circulation of influenza A and B were longer than influenza A seasons, especially in the tropics. DISCUSSION: Our findings show that influenza seasonality is less well defined in the tropics than in temperate regions. This has important implications for vaccination programmes in these countries. High-quality influenza surveillance systems are needed in the tropics to enable decisions about when to vaccinate. |
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